Buy KPV

Anti-Inflammatory Effects: Research suggests that KPV, a C-terminal fragment of alpha-MSH, exhibits potent anti-inflammatory effects without the pigmentary side effects of alpha-MSH [1]. In murine colitis models, KPV accelerated recovery, reduced weight loss, and decreased inflammatory cell infiltration and myeloperoxidase activity.

Mechanistically, KPV inhibits key inflammatory pathways, including NF-κB and MAP kinase, in intestinal epithelial and immune cells. Unlike alpha-MSH, KPV’s effects are independent of melanocortin receptors, acting instead by suppressing IL-1β functions. Its dual action on inflammation and favorable production properties make KPV a promising therapeutic candidate for immune-mediated conditions like colitis, arthritis, and inflammatory skin and lung diseases.

Gut Health Support: Research on KPV shows it supports gut and intestinal barrier health by reducing inflammation and promoting mucosal healing. It is transported into intestinal epithelial and immune cells via hPepT1, enabling intracellular anti-inflammatory effects [4]. In colitis models, KPV delivered through hyaluronic acid-functionalized nanoparticles improved mucosal healing, reduced TNF-α expression, and preserved colon length, indicating less severe inflammation [5].

Studies have also shown that KPV inhibits NF-κB and MAP kinase pathways, reducing pro-inflammatory cytokines. The findings suggest that KPV holds great potential as a treatment for inflammatory bowel disease (IBD). By improving delivery, reducing inflammation, and reinforcing the intestinal barrier, KPV emerges as a promising contender for future IBD therapies [6].

Skin Healing and Protection: Research indicates that KPV enhances skin health, wound healing, and protection through its anti-inflammatory, antioxidative, and cytoprotective properties. It accelerates wound healing by modulating inflammation, supporting collagen turnover, and protecting skin cells [7].

Studies have also shown it shields keratinocytes from oxidative stress and inflammation caused by environmental pollutants like PM10, reducing ROS production, apoptosis, and IL-1β secretion. Advanced delivery methods, such as microneedles and iontophoresis, significantly improve KPV’s skin penetration and retention [8].

These findings highlight KPV’s potential as a therapeutic agent for treating wounds, skin ulcers, and pollution-induced skin damage, with promising applications in dermatology and functional cosmetics for skin protection and repair [9].

Immune Balance: Research has shown that the KPV peptide promotes immune balance by modulating inflammatory pathways and suppressing excessive immune responses. Studies have demonstrated that it inhibits NF-κB signaling, stabilizes IκBα, and prevents nuclear translocation of p65RelA, reducing pro-inflammatory cytokines like IL-8 and eotaxin [10].

KPV also interacts with importin-α3 to block inflammatory signaling. These effects have been demonstrated in airway epithelial cells, highlighting KPV’s potential to regulate immune responses in conditions like asthma. Its anti-inflammatory properties make it a promising therapeutic for immune-mediated diseases [11].

Antimicrobial Properties: Research has demonstrated that KPV exhibits antimicrobial, antioxidant, and antifibrotic properties. Derived from α-MSH, studies have shown that KPV reduces oxidative stress and inflammation by inhibiting NF-κB activation and pro-inflammatory cytokine production [10]. It also prevents fibrosis by modulating fibroblast activity, reducing collagen and α-SMA production in fibrotic tissues [12].

These properties, combined with its favorable safety profile, make KPV a promising therapeutic candidate for managing chronic inflammation, fibrosis, and related organ dysfunction, as well as protecting against microbial and oxidative damage.