Buy MOTS-C Peptide

Improved Metabolic Homeostasis & Insulin Sensitivity:Research shows that MOTS-c plays a key role in improving metabolic homeostasis and insulin sensitivity. Studies have demonstrated that it activates the AMPK pathway, upregulating GLUT4 in skeletal muscle and enhancing glucose uptake [1]. In an experiment in high-fat diet-fed mice, MOTS-c reduced body weight, food intake, and blood glucose levels while significantly improving systemic insulin sensitivity [2].

It also reduces lipid accumulation, such as ceramides, linked to insulin resistance. MOTS-c regulates stress adaptation-related genes via retrograde signaling to the nucleus, influencing energy metabolism, inflammation, and aging-related pathologies [3]. These findings highlight its potential for managing metabolic disorders like diabetes, obesity, and age-related insulin resistance.

Regulation of Adipose Tissue, Thermogenesis and Fat Metabolism: Research shows that MOTS-c enhances adipose tissue regulation, thermogenesis, and fat metabolism by promoting the “browning” of white adipose tissue and activating brown adipose tissue (BAT). A study in mice highlighted that MOTS-c reduced lipid droplet size, improved triglyceride profiles, and maintained higher body temperatures during cold exposure.

These effects, mediated by the ERK signaling pathway, upregulate thermogenic gene expression, highlighting MOTS-c’s potential as a therapeutic strategy to improve lipid metabolism and enhance cold adaptation under stress conditions [4].

Enhanced Exercise Capacity, Muscle Function, Physical Performance: Research suggests that MOTS-c enhances exercise capacity, muscle function, and physical performance across various ages. A study in mice showed that MOTS-c improved physical performance, regulated skeletal muscle metabolism, and enhanced adaptation to metabolic stress [2].

Studies have also shown that exercise induces endogenous MOTS-c expression in humans, linking it to improved metabolic fitness [1]. In rats, combining MOTS-c with exercise significantly enhanced myocardial mechanical efficiency and systolic function compared to exercise alone [5]. These findings highlight MOTS-c’s potential to boost physical performance, promote healthy aging, and optimize cardiovascular and muscular adaptations to exercise.

Cardiovascular & Cardioprotective Effects: Studies show that MOTS-c possesses strong cardioprotective properties. This is because it can help combat oxidative stress and inflamation whilst controlling overall energy too. Research in heart failure mouse model has demonstrated that MOTS-c can inhibit the inflammation, promote antioxidant capacity and activate AMPK pathway to prevent cardiac dysfunction and remodeling [6].

The peptide improves mitochondrial respiration, ameliorate cardiac hypertrophy and glucose homeostasis in diabetic rats [7]. Furthermore, evidence supports that combined treatment of MOTS-c with exercise enhanced myocardial mechanical efficiency, systolic function and cardiac structure [5]. These results underscore the peptide’s potential for correcting heart failure, diabetic cardiomyopathy and maintaining cardiovascular vitality.

Anti-Oxidative, Anti-Inflammatory, Stress Adaptation, and Aging-Related Functions: Research shows that MOTS-c is induced by stress and translocates to the nucleus to regulate stress adaptation genes. It reduces reactive oxygen species (ROS), promotes mitochondrial biogenesis, fusion, and mitophagy, and alleviates mitochondrial dysfunction [1]. MOTS-c suppresses pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-1β) in models of sepsis, lung injury, and inflammatory pain. Additionally, late-life intermittent MOTS-c treatment in mice improved physical capacity and healthspan, highlighting its potential in promoting stress resilience and healthy aging [2].

Potential Benefits for Neuroprotection, Cognition, and Beyond: Studies suggest that MOTS-c may help protect the brain and support metabolism. In Alzheimer’s models, it improved memory, reduced brain inflammation, and lowered harmful immune responses in the hippocampus [8].

It also helps regulate pancreatic cells by lowering insulin release, improving insulin sensitivity, increasing glucagon production, and protecting insulin-producing cells from damage [9]. These effects suggest MOTS-c could protect against brain diseases, boost memory, and support healthy metabolism, especially in aging-related conditions.

Buy MOTS-C Pre-Mixed Peptide Pen from Peptide Works. The 10 mg cartridge is available individually or as part of a full kit that includes a reusable pen, needle tips, and a compact carry case designed for ease and precision.