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CJC-1295 DAC is a synthetic peptide primarily used in research settings to study its effects on growth hormone release and related physiological processes. The peptide is a modified version of growth hormone-releasing hormone (GHRH), engineered with a Drug Affinity Complex (DAC) to extend its half-life and enhance its effectiveness.
This modification helps it remain active in the body for longer, making it a focus of studies on muscle growth, fat loss, and anti-aging. Researchers often study its effects, safety, and potential benefits in both clinical and experimental settings.
CJC-1295 DAC works by mimicking a hormone in the body called the growth hormone-releasing hormone (GHRH). It binds to GHRH receptors located on somatotroph cells within the anterior pituitary gland. This binding activates the cAMP signaling pathway, also known as the cyclic adenosine monophosphate pathway, and triggers the release of growth hormone (GH) into the bloodstream.
This peptide differs from natural GHRH in that it includes a Drug Affinity Complex (DAC), which extends its half-life. This modification protects it from being broken down by enzymes and lets it bind to albumin in the blood. As a result, it stays active longer, leading to a sustained and increased release of growth hormone over several days.
Higher levels of growth hormone (GH) trigger the liver to produce insulin-like growth factor 1 (IGF-1), which is essential for carrying out the effects of GH. IGF-1 supports tissue growth, helps repair muscles, improves fat metabolism, and aids in other regenerative processes. Because of these benefits, CJC-1295 DAC is being widely researched for its potential in muscle growth, fat loss, and anti-aging treatments.
Boosted IGF-1 Levels: CJC-1295 DAC has been shown to reliably increase IGF-1 levels by stimulating sustained GH release. In one human trial, a single injection elevated IGF-1 levels for 9–11 days above baseline. Multiple doses maintained raised IGF-1 for up to 28 days. Higher IGF-1 supports tissue repair, muscle hypertrophy, and metabolic regulation, including enhanced fat metabolism [1].
Enhanced Fat Loss: CJC-1295 DAC has been shown to increase growth hormone (GH) levels 2 to 10-fold for six days after a single dose, and IGF-1 levels 1.5 to 3-fold for up to 9-11 days. Since GH promotes lipolysis (the breakdown of fat) and IGF-1 supports improved metabolism and lean tissue, these elevated hormone levels have the potential to enhance fat loss and improve body composition in humans [1].
Muscle Growth & Recovery: Scientific studies & lab-report data suggest CJC-1295 DAC increases growth hormone (GH) and insulin-like growth factor-1 (IGF-1), which drive protein synthesis and cell regeneration, key for muscle growth and recovery. Animal models show increases in lean body mass, improved nitrogen retention, and faster healing of soft-tissue injury. In humans, single doses elevate growth hormone and IGF-1 levels, aiding anabolic and repair processes [1].
Improved Sleep & Recovery: Research suggests CJC-1295 DAC may enhance sleep and recovery by promoting growth hormone (GH) secretion, which is closely tied to deep sleep cycles. Research shows that growth hormone (GH) levels are highest during slow-wave sleep (SWS), the deepest phase of sleep [2]. Deep sleep is vital for your body’s rest, recovery, and brain function. Research shows that a lack of sleep can decrease important growth factors like IGF-1, but getting enough sleep can restore them. This proves how crucial sleep is for balancing the body’s growth hormone and IGF-1 levels [3].
Skin, Hair & Anti-Aging Effects: Research shows this peptide boosts GH and IGF-1, which supports anti-aging effects and improves skin, hair, and nails. Studies suggest growth hormone (GH) and insulin-like growth factor 1 (IGF-1) stimulate collagen synthesis within skin fibroblasts and the connective tissues of tendons and muscles, helping to improve their elasticity and strength [4]. IGF-1 also promotes hair follicle anagen-phase duration, upregulates anti-apoptotic proteins, and supports hair shaft growth [5].
Increased GH Secretion: CJC-1295 DAC stimulates the pituitary to secrete significantly more growth hormone (GH), raising both basal (trough) and mean GH levels by sustained stimulation. With the DAC moiety, the peptide’s half-life is extended to ~5.8–8 days, allowing less frequent dosing compared to native GHRH (≈30 minutes) [6].
[1] S L Teichman, A Neale, B Lawrence, C Gagnon, et al (2005). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults – Journal of Clinical Endocrinology and Metabolism, 2006 Mar, Volume 91 (Issue 3), Pages 799-805.
[2] E Van Cauter and L Plat (1996) Physiology of growth hormone secretion during sleep – Journal of Pediatrics, 1996 May, Volume 128 (5 Pt 2), Pages S32-7.
[3] M Chennaoui, D L̩ger, and D Gomez-Merino (2020) Sleep and the GH/IGF-1 axis: Consequences and countermeasures of sleep loss/disorders РSleep Medicine Reviews, Volume 49, February 2020, Page 101223.
[4] S Doessing, L Holm, K M Heinemeier, U Feldt-Rasmussen, et al (2010) GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients – European Journal of Endocrinology, 2010 Dec, Volume 163 (Issue 6), Pages 853-62.
[5] W-J Hsieh, W-Y Qiu, I Percec and T-M Chang (2025) Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential – Current Issues in Molecular Biology 2025, Volume 47 (Issue 9), Page 773.Â
[6] M Ionescu and L A Frohman (2006) Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog – Journal of Clinical Endocrinology & Metabolism, 2006 Dec, Volume 91 (Issue 12), Pages 4792-7.
The answers to the most frequently asked questions about CJC-1295 DAC.
Buy CJC-1295 DAC Peptide Nasal Spray from Peptide Works available in 15ml and 30ml glass spray bottles offering a non-invasive administration route ideal for research applications.
CJC-1295 comes in two forms: with DAC and without DAC. The DAC version has a longer half-life of 6-8 days, providing sustained effects and requiring only 1-2 injections per week. In contrast, the non-DAC version has a much shorter half-life of 30 minutes, needing daily or multiple daily injections for short-term growth hormone stimulation.
CJC-1295 DAC is legal to buy only for research use. The FDA has not approved it for human use or medical treatment. It is sold by research suppliers for laboratory studies under controlled conditions. Laws differ by region, so buyers should review local and federal rules before purchase. Researchers must handle and store CJC-1295 DAC safely and use it only for authorized research purposes.
CJC-1295 DAC may cause mild side effects in research studies. Reported effects include redness or swelling at the injection site, headache, flushing, or water retention in test models. Some studies also show changes in appetite or fatigue. Research is still limited, and effects can vary by dose and conditions. Researchers should handle it carefully and follow all lab safety and testing guidelines.
The half-life of CJC-1295 DAC is approximately 6 to 8 days. This long duration comes from the Drug Affinity Complex (DAC), which allows the peptide to bind to albumin in the bloodstream. As a result, growth hormone release remains elevated for nearly a week, enabling once or twice-weekly injections.
This blog explores whether CJC-1295 with DAC can boost testosterone levels by stimulating growth hormone pathways. It examines its effects on Leydig cells, enzyme activity, and protein synthesis in testosterone production.
This blog explores the potential cancer risks associated with growth hormone peptides like CJC-1295, Ipamorelin, and Sermorelin. It examines their effects on cellular growth, IGF-1 production, and DNA repair pathways in laboratory studies.
This blog explores the safety and benefits of CJC-1295 Without DAC, a short-acting growth hormone secretagogue. Unlike its DAC counterpart, it mimics natural hormone pulses, reducing receptor desensitization and long-term risks. The blog highlights its potential for fat loss, metabolic health, and safer research applications, emphasizing its alignment with natural body rhythms.
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Peptide Works website: https://peptide-works.com/ is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
