Buy P-21 Peptide

Neurogenesis and Cognitive Function: Research has shown that P21 peptide enhances neurogenesis and cognitive function by promoting the proliferation and maturation of new neurons in the hippocampal dentate gyrus, an important area for memory formation [1].

Studies have demonstrated that it enhances synaptic plasticity, the brain’s ability to strengthen or weaken synaptic connections in response to activity, essential for learning and memory. This includes promoting dendritic branching (growth of neuron extensions) and synapse formation (connections between neurons) [2].

Research experiments have also shown that P21 increases brain-derived neurotrophic factor (BDNF) expression, supporting neuronal survival and plasticity. In aged rodents and Alzheimer’s models, P21 reversed cognitive decline, rescued synaptic deficits, and improved learning, making it a promising therapeutic candidate [3].

Neuroprotection and Alzheimer’s Disease Pathology: P21 peptide demonstrates neuroprotective effects and potential in mitigating Alzheimer’s-type pathology. In 3×Tg-AD mice, P21 treatment reduced tau hyperphosphorylation, slowed amyloid-β (Aβ) pathology progression, and prevented neurodegeneration. It also rescued episodic memory impairments and reduced mortality rates.

Additionally, P21 decreased markers of glial activation, such as astrogliosis and microgliosis, in retinal studies, suggesting broader anti-inflammatory effects in the central nervous system. By enhancing neurogenesis, synaptic plasticity, and neuronal health, P21 offers promise as a therapeutic candidate for Alzheimer’s disease and other neurodegenerative conditions, potentially preventing cognitive decline and preserving neural integrity in aging and disease contexts.

Mechanistic Pathways: Research has shown that P21 peptide has an effect on important mechanistic pathways. It raises levels of Brain-Derived Neurotrophic Factor (BDNF), which in turn activates TrkB/PI3K/Akt/GSK-3β signaling downstream. This helps neurons stay alive, supports synaptic plasticity, and promotes protein synthesis, all of which are important for synaptic development. This pathway controls transcription, translation, and protein movement, all of which are important for neurogenesis and plasticity [7].

P21 also blocks signaling by Leukemia Inhibitory Factor (LIF), which promotes cell cycle arrest and apoptosis. P21 promotes neurogenesis and reduces the negative effects on neuronal development by blocking LIF signaling. These two mechanisms make P21 a promising treatment for neurodegenerative and cognitive disorders that can improve neurogenesis, synaptic health, and resilience [8].

Stability and Delivery Improvements: Research shows that the P21 peptide is more stable and better delivered than larger neurotrophic proteins, like CNTF. Because P21 is a small peptide, it can cross the blood-brain barrier (BBB) more easily and remains stable longer in plasma and the gut. This means it reaches the brain more effectively.

These characteristics make P21 a promising treatment because it avoids the common problems with larger proteins, such as poor BBB penetration and quick breakdown, ensuring better delivery and effectiveness for neurodegenerative and cognitive disorders [9].