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CJC-1295 DAC is a long-acting synthetic analogue of growth hormone-releasing hormone (GHRH). This tetra-substituted peptide has 30 amino acids. Its structure is modified from the original GHRH sequence to prevent metabolic degradation. According to research, adding the Drug Affinity Compound (DAC) enables it to covalently bind to blood albumin, greatly increasing its half-life to about one week.
This modification creates a sustained “bleed” effect, leading to a more stable and prolonged elevation of growth hormone and IGF-1 levels, which is of considerable interest for therapeutic and research applications. Potential benefits include increased muscle mass and fat loss, improved bone density, and anti-aging properties. Researchers often study its effects, safety, and potential benefits in both clinical and experimental settings.
Peptide Sequence (IUPAC Condensed): H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
Molecular Formula: C152H252N44O42
Molecular Weight: 3367.9 g/mol
Synonyms: DAC:GRF
View the CJC-1295 DAC Certificate Of Analysis (COA)
View the CJC-1295 DAC High Performance Liquid Chromatography (HPLC)
CJC-1295 with Drug Affinity Complex is a long-acting synthetic analogue of growth hormone-releasing hormone (GHRH), distinguished by its specialized amino acid sequence and DAC modification. Its primary mechanism of action involves mimicking endogenous GHRH to elevate growth hormone (GH) levels.
When administered, the peptide, modified with the help of a lysine linker, travels to the anterior pituitary gland, where it binds to GHRH receptors (GHRHr) on somatotropic cells. This binding activates the cAMP signaling pathway (also called the cyclic adenosine monophosphate pathway), triggering the release of growth hormone into the bloodstream. The peptide’s stable association with the blood protein albumin ensures sustained activity, promoting the synthesis and pulsatile release of endogenous growth hormone.
The peptide’s extended half-life is attributed to its unique amino acid sequence and DAC modification. The DAC component binds to albumin, which helps stabilize the peptide in the bloodstream. This binding protects it from rapid breakdown by the enzyme dipeptidyl peptidase-4 (DPP-4) and slows its clearance by the kidneys, allowing growth hormone levels to remain elevated for longer.
The stable complex formed between CJC-1295 DAC and albumin, facilitated by its drug affinity complex modification and lysine linker, acts as a reservoir for the gradual release of the active peptide. This mechanism supports continuously elevated growth hormone levels, which in turn increase insulin-like growth factor 1 (IGF-1) levels for up to a week following a single administration.
Buy CJC-1295 DAC Peptide Vial from Peptide Works, which contains over 99% pure lyophilized peptide and is available in 2mg, 5mg, and 10mg options, or as complete kits supplied with bacteriostatic water and syringes for easy preparation.
Boosted IGF-1 Levels: This peptide has been shown to reliably increase IGF-1 levels by stimulating sustained GH release. In one human trial, a single injection elevated IGF-1 levels for 9–11 days above baseline. Multiple doses maintained raised IGF-1 for up to 28 days. Higher IGF-1 supports tissue repair, muscle hypertrophy, and metabolic regulation, including enhanced fat metabolism [1].
Enhanced Fat Loss: Research suggests it has been shown to increase growth hormone (GH) levels 2 to 10-fold for six days after a single dose, and IGF-1 levels 1.5 to 3-fold for up to 9-11 days. Since GH promotes lipolysis (the breakdown of fat) and IGF-1 supports improved metabolism and lean tissue, these elevated hormone levels have the potential to enhance fat loss and improve body composition in humans [1].
Muscle Growth & Recovery: Scientific studies & lab-report data suggest this peptide increases growth hormone (GH) and insulin-like growth factor-1 (IGF-1), which drive protein synthesis and cell regeneration, key for muscle growth and recovery. Animal models show increases in lean body mass, improved nitrogen retention, and faster healing of soft-tissue injury. In humans, single doses elevate growth hormone and IGF-1 levels, aiding anabolic and repair processes [1].
Improved Sleep & Recovery: Research suggests it may enhance sleep and recovery by promoting growth hormone (GH) secretion, which is closely tied to deep sleep cycles. Research shows that growth hormone (GH) levels are highest during slow-wave sleep (SWS), the deepest phase of sleep [2]. Deep sleep is vital for your body’s rest, recovery, and brain function. Research shows that a lack of sleep can decrease important growth factors like IGF-1, but getting enough sleep can restore them. This proves how crucial sleep is for balancing the body’s growth hormone and IGF-1 levels [3].
Skin, Hair & Anti-Aging Effects: Research shows this peptide boosts GH and IGF-1, which supports anti-aging effects and improves skin, hair, and nails. Studies suggest growth hormone (GH) and insulin-like growth factor 1 (IGF-1) stimulate collagen synthesis within skin fibroblasts and the connective tissues of tendons and muscles, helping to improve their elasticity and strength [4]. IGF-1 also promotes hair follicle anagen-phase duration, upregulates anti-apoptotic proteins, and supports hair shaft growth [5].
Increased GH Secretion: The peptide stimulates the pituitary to secrete significantly more growth hormone (GH), raising both basal (trough) and mean GH levels by sustained stimulation. With the DAC moiety, the peptide’s half-life is extended to ~5.8–8 days, allowing less frequent dosing compared to native GHRH (≈30 minutes) [6].
Buy CJC-1295 DAC Pre-Mixed Peptide Pen from Peptide Works where each 2mg cartridge is available individually or as a complete kit that includes a reusable pen, needle tips, and a carry case for convenient and precise research use.
[1] S L Teichman, A Neale, B Lawrence, C Gagnon, et al (2005). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults – Journal of Clinical Endocrinology and Metabolism, 2006 Mar, Volume 91 (Issue 3), Pages 799-805.
[2] E Van Cauter and L Plat (1996) Physiology of growth hormone secretion during sleep – Journal of Pediatrics, 1996 May, Volume 128 (5 Pt 2), Pages S32-7.
[3] M Chennaoui, D L̩ger, and D Gomez-Merino (2020) Sleep and the GH/IGF-1 axis: Consequences and countermeasures of sleep loss/disorders РSleep Medicine Reviews, Volume 49, February 2020, Page 101223.
[4] S Doessing, L Holm, K M Heinemeier, U Feldt-Rasmussen, et al (2010) GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients – European Journal of Endocrinology, 2010 Dec, Volume 163 (Issue 6), Pages 853-62.
[5] W-J Hsieh, W-Y Qiu, I Percec and T-M Chang (2025) Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential – Current Issues in Molecular Biology 2025, Volume 47 (Issue 9), Page 773.
[6] M Ionescu and L A Frohman (2006) Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog – Journal of Clinical Endocrinology & Metabolism, 2006 Dec, Volume 91 (Issue 12), Pages 4792-7.
The DAC version has a longer half-life of 6-8 days, providing sustained effects and requiring only 1-2 injections per week. In contrast, the non-DAC version has a much shorter half-life of 30 minutes, needing daily or multiple daily injections for short-term growth hormone stimulation.
It is only legal to buy CJC-1295 DAC for research use. The FDA has not approved it for human use or medical treatment. It is sold by research suppliers for laboratory studies under controlled conditions. Laws differ by region, so buyers should review local and federal rules before purchase. Researchers must handle and store the peptide safely and use it only for authorized research purposes.
It may cause mild side effects in research studies. Reported effects include redness or swelling at the injection site, headache, flushing, or water retention in test models. Some studies also show changes in appetite or fatigue. Research is still limited, and effects can vary by dose and conditions. Researchers should handle it carefully and follow all lab safety and testing guidelines.
The half-life of the peptide is approximately 6 to 8 days. This long duration comes from the Drug Affinity Complex, which allows the peptide to bind to albumin in the bloodstream. As a result, growth hormone release remains elevated for nearly a week, enabling once or twice-weekly injections.
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Peptide Works website: https://peptide-works.com/ is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
