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HGH Fragment 176-191 is a synthetic peptide that represents a specific portion of the full human Growth Hormone (HGH) molecule. It consists of the amino acid sequence from positions 176 to 191, located at the C-terminus of the parent hormone.
This fragment was designed to focus on HGH’s fat-regulating properties without causing other common effects of the full hormone, like changes in insulin sensitivity or cell growth. By isolating this specific sequence, researchers can study its metabolic effects in a more precise and controlled way.
HGH Fragment 176-191 is primarily studied for its role in fat metabolism. Research shows it promotes fat breakdown (lipolysis) and inhibits fat creation (lipogenesis), making it valuable for studying body composition and energy regulation. Its targeted action on fat tissue allows focused research without systemic effects seen with full growth hormone use.
HGH Fragment 176-191 operates by targeting the body’s fat metabolism processes. This synthetic peptide comes from the C-terminal part of human growth hormone (hGH), specifically amino acids 176-191. It’s designed to target fat regulation only, without causing other effects of full HGH, like changing blood sugar or increasing cell growth.
The fragment operates by stimulating lipolysis, which is the breakdown of stored fats (triglycerides) into free fatty acids and glycerol. The body can use these byproducts as energy. At the same time, HGH Fragment 176-191 blocks lipogenesis, which is the process of creating new fat stores.
This makes it a valuable tool for researchers studying how the body burns fat and maintains energy balance. Its focus on fat tissue ensures that its effects stay localized, reducing the wider impacts usually seen with full growth hormone treatments.
Fat Loss and Weight Management:Research has shown that HGH Fragment 176-191 enhances fat loss by increasing lipolysis and inhibiting lipogenesis, particularly in abdominal fat. Studies in rodents show it reduces weight gain and fat accumulation without affecting blood sugar or muscle growth [1].
The peptide boosts energy expenditure and fat oxidation while reducing lipogenic activity in adipose tissue. Additionally, it increases beta-adrenergic receptor expression, enhancing fat breakdown sensitivity, making it a promising candidate for obesity treatment [2].
Blood Glucose Levels: Research has shown that HGH Fragment 176-191 has minimal impact on blood glucose levels. Studies in rats show it causes a short-lived rise in blood glucose and a sustained increase in plasma insulin. However, peptides containing the 178-191 sequence, including Fragment 176-191, temporarily reduce insulin sensitivity in insulin tolerance tests. These effects suggest that while the fragment influences glucose metabolism, its impact is transient and depends on the peptide’s specific sequence and configuration [3].
Promise in Repairing Cartilage: Research has shown that HGH Fragment 176-191 (AOD-9604) shows potential in cartilage repair. In a rabbit knee osteoarthritis model, intra-articular peptide injections improved cartilage regeneration, as evidenced by better morphological and histopathological scores.
Combining HGH frag with hyaluronic acid (HA) further enhanced these effects, reducing cartilage degeneration and shortening lameness duration more effectively than AOD9604 or HA alone. These findings suggest the peptide may support cartilage repair and joint health, particularly when paired with HA [4].
[1] M A Heffernan, W J Jiang, A W Thorburn, and F M Ng (2000) Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism – Am J Physiol Endocrinol Metab, 2000 Sep, Volume 279 (Issue 3), Pages E501-7.
[2] M Heffernan, R J Summers, A Thorburn, E Ogru, et al (2001) The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice – Endocrinology, 2001 Dec, Volume 142 (Issue 12), Pages 5182-9.
[3] F M Ng and J Bornstein (1978) Hyperglycemic action of synthetic C-terminal fragments of human growth hormone – American Journal of Physiology, 1978 May, Volume 234 (Issue 5), Pages E521-6.
[4] Dong Rak Kwon and Gi Young Park (2015) Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model – Annals of Clinical and Laboratory Science, 2015 Summer, Volume 45 (Issue 4), Pages 426-32.
[5] M M Habibullah, S Mohan, Nl Kashan Syed, H A Makeen, et al (2022) Human Growth Hormone Fragment 176–191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells – Drug Design, Development and Therapy, 2022 Jun 27, Volume 16, Pages 1963–1974.Â
The answers to the most frequently asked questions about HGH Fragment 176-191.
Buy HGH Fragment 176-191 Pre-Mixed Peptide Pen from Peptide Works. Each 5mg cartridge can be purchased individually or as part of a complete kit that includes a reusable pen, needle tips, and a carry case for simple and precise preparation.
HGH Fragment 176-191 supports fat metabolism by signaling the body to use stored fat for energy and reduce new fat formation. Lab and animal research shows promising fat-reducing effects, but verified human data are still limited. Early findings suggest it may help guide future studies on targeted fat-loss pathways and metabolic health.
HGH Fragment 176-191 is legal to purchase in the United States for laboratory and scientific research only. The Food and Drug Administration (FDA) has not approved this peptide for human consumption or medical use. It may be researched for its potential impact on fat metabolism and body composition under controlled laboratory conditions.
Yes. The World Anti-Doping Agency (WADA) bans HGH Fragment 176-191 under its list of prohibited substances. It falls under the category of growth hormone fragments and similar peptides. Athletes cannot use or possess it in or out of competition. Any use in sports may lead to disqualification or suspension.
Research on HGH Fragment 176-191 offers very limited information about its side effects or long-term safety. Some mild reactions, such as slight irritation at the injection site, may occur during testing, but these effects are not well studied. Current data come mainly from related peptides, so human safety outcomes remain uncertain.
This blog looks at how the 176-191 Fragment could help with weight loss. It comes from human growth hormone and works by targeting fat cells to break them down, all without losing muscle. The blog will cover how it helps metabolism, how it compares to other similar peptides like AOD-9604, and how it can reduce stubborn fat in specific areas.
This blog compares HGH Fragment 176-191 and full-length HGH191AA peptides, focusing on their structural and functional differences. HGH Fragment targets fat metabolism with fewer variables, while HGH191AA offers broader effects across multiple tissues. It guides researchers in selecting the right peptide based on study goals, emphasizing their unique research applications.
This blog explains how CJC-1295 and HGH peptides compare in research. It looks at safety concerns such as injection reactions, blood sugar, and heart effects, and how each affects natural hormone function. It also covers dosing, long-term use, and why labs choose one compound over another for safer research planning.
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Peptide Works website: https://peptide-works.com/ is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
