Buy MK-677 Capsules from Peptide Works. Each capsule contains 10 mg of high-quality Ibutamoren, available in bottles of 60 capsules for consistent and reliable use.
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MK-677, or Ibutamoren, is an orally active growth hormone secretagogue (GHS) that stimulates the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) by mimicking ghrelin, a natural hormone. Unlike injectable GH therapies, MK-677 offers a convenient oral option, making it a focus of clinical and research interest.
MK-677 is under research for its potential to increase growth hormone and IGF-1 levels. This could help fight muscle wasting, improve bone density, support brain health, and lead to better sleep.
Sequence: 2-Amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4′-piperidin]-1′-yl)-1-oxopropan-2-yl)-2-methylpropanamide
Molecular Formula: C27H36N4O5S
Molecular Weight: 528.7 g/mol
Synonyms: Ibutamoren, Nutrobal
MK-677 works by binding to ghrelin receptors, specifically the GHS-R1a receptors in the brain, including the hypothalamus and pituitary gland. This triggers the body to release growth hormone (GH). Since MK-677 mimics the action of ghrelin, a hormone that not only boosts appetite but also stimulates GH release, it effectively enhances the production of growth hormone.
Additionally, it increases the level of insulin-like growth factor 1 (IGF-1) in the liver, contributing to its effects on growth, cell repair, and metabolism. Unlike GH injections, MK-677 preserves the body’s natural GH pulsatility and does not suppress cortisol or testosterone levels. This makes it a safer, long-term option for research into growth and metabolic health.
Buy MK-677 Capsules from Peptide Works. Each capsule contains 10 mg of high-quality Ibutamoren, available in bottles of 60 capsules for consistent and reliable use.
Improved Nitrogen Balance & Muscle Anabolism: Research has shown that MK-677 effectively reverses diet-induced negative nitrogen balance, promoting muscle anabolism. In a study of calorically restricted healthy men, MK-677 (25 mg/day) improved nitrogen balance from -2.67 g/day to +0.31 g/day, compared to -1.48 g/day with placebo.
It increased growth hormone (GH) and IGF-1 levels, supporting protein retention and lean mass preservation. These findings suggest MK-677’s potential for combating catabolic states and preserving muscle in conditions of caloric restriction or illness.
Enhanced GH/IGF-1 Levels and Potential for Lean Muscle Growth: Research has demonstrated that MK-677 significantly increases growth hormone (GH) and IGF-1 levels, helping combat age-related muscle loss. In a study of older adults (ages 60–81), MK-677 was shown to raise GH to youthful levels and increase fat-free mass (FFM) by 1.1 kg over 12 months, compared to a 0.5 kg loss with placebo. While no significant changes in strength or abdominal fat were observed, MK-677 shows promise for preserving lean mass and addressing sarcopenia in aging populations.
Bone Health and Markers of Bone Turnover: Research indicates that MK-677 significantly influences bone remodeling by increasing markers of both bone formation and resorption. In a study on obese young men, 8 weeks of MK-677 treatment raised bone formation markers, such as type I procollagen (+23%) and procollagen III peptide (+28%), and bone resorption markers, like type I collagen telopeptide (+26%) [3].
In another study on postmenopausal women, MK-677 combined with alendronate improved femoral neck bone mineral density (BMD) by 4.2% versus 2.5% with alendronate alone. These findings suggest MK-677’s potential to enhance bone health, though further studies are needed to confirm long-term benefits and broader BMD improvements [4].
Sleep and Recovery: Research has shown that MK-677 can improve sleep quality, likely by affecting growth hormone (GH) levels. For young adults, a high dose of MK-677 led to a 50% increase in deep (Stage IV) sleep and over 20% more REM sleep, also cutting down on sleep problems. Older adults saw almost 50% more REM sleep and a shorter time to reach REM sleep. Better sleep could help with recovery, but more extensive research is needed to confirm its impact on muscle and tissue repair [5].
Potential in Age-Related and Catabolic Conditions: MK-677 shows promise in addressing age-related and catabolic conditions by increasing growth hormone (GH) and IGF-1 levels, which decline with age [2]. In older adults, MK-677 significantly increased fat-free mass (+1.1 kg) over 12 months, compared to a loss with placebo [1]. It also improved nitrogen balance in caloric restriction studies, suggesting potential for preserving muscle and combating catabolic states. While generally well-tolerated, further research is needed to confirm long-term benefits in sarcopenia and frailty management [3].
[1] M G Murphy, L M Plunkett, B J Gertz, et al (1998) MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism – Journal of Clinical Endocrinology & Metabolism, 1998 Feb, Volume 83 (Issue 2), Pages 320-5.
[2] R Nass, S S Pezzoli, M Clancy Oliveri, et al (2008) Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults: A Randomized, Controlled Trial – Annals of Internal Medicine, 2008 Nov 4, Volume 149 (Issue 9), Pages 601–611.Â
[3] J Svensson, C Ohlsson, J O Jansson, et al (1998) Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males – Journal of Bone and Mineral Research, 1998 Jul, Volume 13 (Issue 7), Pages 1158-66.
[4] M G Murphy, S Weiss, M McClung, et al (2001) Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women – Journal of Clinical Endocrinology & Metabolism, 2001 Mar, Volume 86 (Issue 3), Pages 1116-25.
[5] G Copinschi, R Leproult, A Van Onderbergen, et al (1997) Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man – Neuroendocrinology, 1997 Oct, Volume 66 (Issue 4), Pages 278-86.
The answers to the most frequently asked questions about the peptide.
MK-677 may improve sleep quality by boosting growth hormone release during the night. Clinical research shows it can increase deep and REM sleep and shorten the time it takes to enter REM, resulting in longer, more restorative sleep in study participants. These findings suggest MK-677 influences sleep regulation, but its long-term safety and real-world benefits still need more investigation before drawing firm conclusions.
Clinical studies show MK-677 increases growth hormone and IGF-1 levels, which may support muscle and bone mass with aging. However, research has not demonstrated clear improvements in cognition or lifespan. In long-term trials, participants experienced gains in lean mass but showed no measurable increase in strength, memory or functional performance. Additional studies are needed to confirm any true anti-aging or cognitive benefits.
MK-677 is for research use only in the United States and is not approved by the FDA for human consumption. It cannot be sold legally as a dietary supplement. Laws and regulations vary by country, with some allowing controlled research sales and others banning the compound entirely. The World Anti-Doping Agency (WADA) also prohibits MK-677 for all competitive athletes.Â
Clinical studies show that MK-677 can cause increased appetite, water retention, mild swelling, muscle or joint pain, and fatigue in study participants. Some trials also reported higher blood sugar and reduced insulin sensitivity with continued use. These effects occur because MK-677 increases growth hormone and IGF-1 levels. Monitoring these changes is important, as long-term safety and metabolic impacts remain under study.
This blog explores the science behind growth hormone research, focusing on Ibutamoren (MK-677) and peptides such as CJC-1295 and Ipamorelin. It explains how these compounds work, their possible benefits, and their potential to boost natural growth hormone release. The article also offers insights into muscle growth, fat metabolism, and age-related conditions, highlighting their importance in advancing scientific research.
This blog explores the potential benefits and risks of MK-677 (Ibutamoren) for women going through perimenopause. It looks at how this compound affects growth hormone and IGF-1, and how these changes may influence sleep, bone health, cognition, and body composition. While the results appear promising, the article stresses the need for more research and also points out the possible risks.
This blog explores the science behind muscle-building peptides and their role in supporting growth hormone, IGF-1 levels, and protein synthesis. It looks at compounds such as Ipamorelin, CJC-1295, MGF, and MK-677, explaining their potential in muscle growth, recovery and future therapeutic applications. The article also emphasizes their importance in ongoing scientific research.
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