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SNAP-8, or Acetyl Octapeptide-3, is a synthetic peptide composed of eight amino acids. It is an elongated analogue of the well-researched peptide Argireline (Acetyl Hexapeptide-8). Primarily developed for cosmetic applications, SNAP-8 is gaining attention within anti-ageing research for its potential to reduce the appearance of expression lines.
Its mechanism of action, which involves mimicking the N-terminal end of the SNAP-25 protein (Synaptosomal-Associated Protein, 25kDa), makes it a subject of interest for studying muscle contraction pathways at the neuromuscular junction. This relevance extends to dermatology and biochemical research focused on topical agents that can modulate neurotransmitter release non-invasively.
Peptide Sequence (IUPAC Condensed): Ac-DL-Glu-DL-Glu-DL-Met-DL-Gln-DL-Arg-DL-Arg-DL-Ala-DL-Asp-NH2
Molecular Formula: C41H70N16O16S
Molecular Weight: 1075.2 g/mol
Synonyms: Acetyl Octapeptide-3
View the SNAP-8 COA
View the SNAP-8 HPLC
As a SNAP-25 protein fragment, Snap 8 interferes with the SNARE complex by mimicking SNAP-25, thereby reducing muscle contraction by disrupting neurotransmitter release. The SNARE complex, composed of SNAP-25, syntaxin, and synaptobrevin, enables synaptic vesicles to fuse with the neuronal membrane, releasing neurotransmitters such as acetylcholine to trigger muscle contractions.
Snap-8 competes with SNAP-25 in the SNARE complex, disrupting its formation. This reduces acetylcholine release, the neurotransmitter that causes muscle contraction. The result is relaxed facial muscles, especially those forming dynamic wrinkles like crow’s feet and frown lines.
Reduces the appearance of fine lines and wrinkles: SNAP-8 peptide has shown promising results in reducing wrinkle depth and fine lines, particularly in the periorbital and forehead areas. By inhibiting the SNARE complex, SNAP-8 relaxes facial muscles, minimizing dynamic wrinkles.
Studies suggest that topical formulations containing SNAP-8, often combined with other peptides like palmitoyl tripeptide-5, can achieve wrinkle-depth reductions of 25-35% over several weeks. For instance, a 12-week study reported a 26% reduction in periorbital wrinkles using such a combination. While some manufacturer data claim reductions up to 63% under optimized conditions, further independent clinical validation is needed to confirm these results [1].
Muscle Relaxation and Expression Line Prevention: SNAP-8 peptide is theorized to reduce neuromuscular signaling, leading to mild muscle relaxation. By decreasing the intensity of repeated facial muscle contractions, it may help prevent the formation of new expression lines, offering a “Botox-like” effect in a non-invasive, topical form.
A study on Acetyl Hexapeptide-8 (AH8), a similar SNAP25 inhibitor, demonstrated its potential to extend the effects of botulinum toxin (BoNT) therapy in blepharospasm patients, with some experiencing prolonged symptom control of up to 7.1 months. These findings suggest SNAP-8’s promise in reducing dynamic wrinkles and preventing expression lines through gentle muscle relaxation [2].
Enhanced skin texture, firmness, and elasticity: SNAP-8 peptide may contribute to improved skin texture, firmness, and elasticity by reducing mechanical stress on the dermis through decreased muscle contractions and potentially stimulating fibroblast activity. These effects align with findings from a 12-week study on a facial serum, which demonstrated significant improvements in skin firmness (11%), elasticity (18%), and texture (47%).
The study also reported enhanced skin tone, radiance, and resilience, with subjects noting a 43% improvement in overall facial appearance. While SNAP-8’s direct role in fibroblast stimulation is less documented, its ability to reduce dynamic lines indirectly supports smoother, more elastic, and resilient skin over time [3].
[1] T T M Nguyen, E-J Yi, X Jin, et al (2024) Sustainable Dynamic Wrinkle Efficacy: Non-Invasive Peptides as the Future of Botox Alternatives – Cosmetics 2024, Volume 11 (Issue 4), Page 118.
[2] C Lungu, E Considine, S Zahir, et al (2012) Pilot Study of Topical Acetyl Hexapeptide-8 in Treatment of Blepharospasm in Patients Receiving Botulinum Neurotoxin Therapy – European Journal of Neurology, 2012 Nov 12, Volume 20 (Issue 3), Pages 515–518.
[3] F Mccall-Perez, T J Stephens, and J H Herndon Jr (2011) Efficacy and Tolerability of a Facial Serum for Fine Lines, Wrinkles, and Photodamaged Skin – Journal of Clinical Aesthetic Dermatol. 2011 Jul;4(7):51–54.
Buy SNAP-8 Peptide Nasal Spray from Peptide Works. The spray is available in 15ml and 30ml glass bottles, offering a simple and needle-free application method.
The answers to the most frequently asked questions about SNAP 8.
Buy SNAP-8 Pre-Mixed Peptide from Peptide Works. The pre-mixed pen kit includes a 10mg cartridge, supplied with a cartridge pen, needle tips, and carry case for ease of use and accuracy.
SNAP-8 peptide is known for its ability to reduce the look of fine lines and wrinkles. It works by limiting the muscle movements that cause expression lines, helping skin appear smoother and more relaxed. Researchers study it for its potential to improve skin texture and firmness over time.
SNAP-8 and Argireline are both peptides studied for reducing the look of expression lines. SNAP-8 is an updated version of Argireline with two extra amino acids, designed to enhance its wrinkle-smoothing effects. Both target the same nerve-signaling process that causes muscle movement. Researchers often explore SNAP-8 for its stronger potential, but both peptides show similar results in studies.
SNAP-8 peptide has shown good stability and a low toxicity profile in laboratory studies. It is a synthetic peptide researched for its effects on neurotransmitter activity related to muscle movement. The United States Food and Drug Administration (FDA) has not approved SNAP-8 for cosmetic, medical, or injectable use, and there are no clinical safety evaluations for human application.
You can buy SNAP-8 peptide from Peptide Works, a trusted source for high-purity research peptides. Our SNAP-8 is manufactured to high standards and verified for quality before distribution. Order directly from Peptide Works to ensure you’re getting authentic, reliable SNAP-8 for your research needs.
This blog explores SNAP-8, a peptide studied as a potential non-invasive Botox substitute. It delves into how SNAP-8 reduces muscle contraction signals to target expression lines, compares its effects to Botox injections and highlights the role of peptides like GHK-Cu in collagen support and skin firmness.
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