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What Is Semax Peptide?

Semax, a synthetic peptide derived from the adrenocorticotropic hormone (ACTH), was created to enhance cognitive performance and safeguard the brain. Its potential to protect neurons and increase brain power has been extensively studied since it was first developed in Russia.

Semax is known to improve memory, focus, and learning, making it a subject of interest for those seeking cognitive enhancement. Additionally, it shows promise in treating neurodegenerative diseases, stroke, and ADHD. Semax does not change hormone levels like many other peptides do, which might make it a safer option for long-term use. Because of its special structure, it can directly impact brain function and promote mental clarity by crossing the blood-brain barrier.

Peptide Sequence (IUPAC Condensed): H-Met-Glu-His-Phe-Pro-Gly-Pro-OH

Molecular Formula: C37H51N9O10S

Molecular Weight: 813.9 g/mol

Synonyms: ACTH (4-7), Pro-Gly-Pro

View the Semax COA

View the Semax HPLC

Semax Structure
Source: PubChem
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How Does Semax Peptide Work?

Semax works through several pathways. It primarily modulates the brain’s dopaminergic and serotonergic systems, crucial for mood, motivation, and cognitive function. By boosting dopamine and serotonin activity, Semax may enhance concentration, memory, and emotional stability. Furthermore, Semax stimulates Brain-Derived Neurotrophic Factor (BDNF) production. BDNF is vital for neuron survival and development, making Semax a key subject for studies on neurodegenerative conditions and brain injury recovery, as it could aid brain repair or function preservation.

Semax helps reduce stress and acts as an adaptogen by regulating stress-related gene expression, which can calm an overactive hypothalamic-pituitary-adrenal axis (HPA). It also enhances cognitive performance and protects the brain by supporting synaptic plasticity and neuronal communication, which are crucial for learning, memory, and attention. Additionally, it lowers ROS levels by ensuring proper mitochondrial function, directly protecting neurons. These combined effects make Semax a valuable compound for studying cognitive enhancement, neuroprotection, and stress resistance.

Buy Semax Peptide Vial from Peptide Works. This lyophilized powder is over 99% pure and available in 2mg, 5mg, and 30mg vials, supplied in sterile glass containers to ensure quality and stability.

 

Research on Semax Peptide?

Modulation of the Brain’s Neurotransmitter Systems: Research suggests that Semax regulates the brain’s dopaminergic and serotonergic systems by enhancing the turnover and activity of neurotransmitters. Studies have shown that chronic administration of Semax increases serotonin turnover, indicating heightened functional activity in this system.

Additionally, it potentiates dopamine-related effects, such as amplifying the impact of D-amphetamine on dopamine levels and locomotor activity [2]. These findings suggest that Semax’s role in improving mood, motivation, and cognitive processes by regulating key neurotransmitter pathways makes it a promising candidate for neuropsychiatric and cognitive research.

Neurotrophic Effects: Research suggests that Semax enhances neurotrophic activity by increasing brain-derived neurotrophic factor (BDNF) levels, which are critical for synaptic plasticity and neuronal survival.

Studies show that intranasal administration of Semax elevates BDNF protein levels in the basal forebrain and hippocampus, alongside increased expression of its receptor, trkB12 [3]. This modulation of the BDNF/trkB system is linked to improved cognitive functions, such as learning and memory, and highlights Semax’s potential in neuroprotection and recovery from brain injuries [4].

Anti-Stress and Adaptogenic Properties: Semax exhibits anti-stress and adaptogenic properties by modulating stress-induced gene expression and normalizing behavioral changes. Studies show that Semax reduces the negative effects of acute restraint stress (ARS) in rats, including anxiety-related behaviors [5].

It also corrects disrupted gene expression patterns in the hippocampus, particularly those related to immune and nervous system functions [6]. Additionally, Semax prevents stress-induced oxidative damage and normalizes stress-related enzyme production in animal models [7]. These findings highlight its potential as a stress-mitigating agent.

Cognitive Enhancement: Research has demonstrated that Semax improves brain function by increasing levels of brain-derived neurotrophic factor (BDNF) and adjusting a related system in the hippocampus. Studies show it boosts attention and short-term memory in healthy individuals.

In animal models, Semax also enhances learning and memory performance, as demonstrated in tests like passive avoidance tasks [3]. Additionally, it increases serotonin levels, which can further support cognitive processes. These findings suggest Semax has potential as a cognitive enhancer, especially for improving memory and learning.

Neuroprotection: Research has shown that Semax is a synthetic heptapeptide with powerful neuroprotective properties, showing promise in conditions like Alzheimer’s disease (AD) and ischemic stroke. Studies in AD have shown that Semax reduces the production of harmful reactive oxygen species (ROS) by preventing copper ions from reacting with amyloid-beta, protecting brain cells from oxidative damage [8].

In stroke models, the peptide has promoted recovery by boosting neurotrophins (protective proteins), which have helped reduce inflammation and suppress proteins linked to cell death (like MMP-9 and JNK). It also enhances CREB activity, which supports brain repair and protection [9]. These combined effects highlight Semax’s potential to protect neurons, reduce damage, and promote healing in conditions associated with neurodegeneration and ischemia.

Buy Semax Pre-Mixed Peptide from Peptide Works. The pre-mixed pen kit is available in 2mg cartridges, supplied with a cartridge pen, needle tips, and carry case.

 

References

[1] K O Eremin, V S Kudrin, I A Grivennikov, et al (2004) Effect of semax on dopamine- and serotoninergic brain systems – Dokl Biol Sci, 2004 Jan-Feb, Volume 394, Pages 1-3.

[2] K O Eremin, V S Kudrin, P Saransaari, et al (2005) Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents – Neurochemical Research, 2005 Dec, Volume 30 (Issue 12), Pages 1493-500.

[3] O V. Dolotov, E A. Karpenko, L S. Inozemtseva, et al (2006) Semax, an analog of ACTH(4–10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus – Brain Research, Volume 1117, Issue 1, 30 October 2006, Pages 54-60.

[4] Y. A. Sukhanova, M. A. Volodina, E. A. Sebentsova, et al (2018) Long-Term Changes in Behavior and the Content of BDNF in the Rat Brain Caused by Neonatal Isolation: The Effects of an Analog of ACTH(4-10) Semax – Neurochemical Journal, Volume 12, Pages 53–63 (2018).

[5] E V Medvedeva, V G Dmitrieva, O V Povarova, et al (2014) The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis – BMC Genomics. 2014 Mar 24, Volume 15, Page 228.

[6] I B Filippenkov, V V Stavchansky, N Yu Glazova, et al (2021) Antistress Action of Melanocortin Derivatives Associated with Correction of Gene Expression Patterns in the Hippocampus of Male Rats Following Acute Stress – International Journal of Molecular Sciences, 2021 Sep 17, Volume 22 (Issue 18), Page 10054.

[7] M A Samotrueva, A L Yasenyavskaya, V Kh Murtalieva, et al (2019) Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of “Social” Stress – Bulletin of Experimental Biology and Medicine, 2019 Apr, Volume 166 (Issue 6), Pages 754-758.

[8] M F Tomasello, M C Di Rosa, I Naletova, et al (2025) Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing – Bioinorganic Chemistry & Applications, 2025 Jun 3, Volume 2025, Page 4226220. 

[9] O Y Sudarkina, I B Filippenkov, V V Stavchansky, et al (2021) Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4–7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia–Reperfusion – International Journal of Molecular Sciences, 2021 Jun 8, Volume 22 (Issue 12), Page 6179.

 

Semax Peptide FAQ's

The answers to the most frequently asked questions about Semax.

Semax FAQs
Buy Semax Peptide Nasal Spray from Peptide Works. The spray is available in 15ml and 30ml glass bottles, offering a needle-free and convenient administration method.
 
What Are the Cognitive Benefits of Semax?

Semax supports cognitive performance by stimulating brain-derived neurotrophic factor (BDNF) and activating its receptor TrkB, which strengthens memory and learning pathways. Research shows it enhances synaptic signaling, protects neurons from stress, and regulates genes tied to focus and attention. In animal studies, Semax also improves neurotransmission and helps maintain healthy brain function under demanding conditions.

Can Semax Reduce Anxiety and Stress?

Semax helps the brain respond better to stress by balancing key chemical messengers. Studies show it supports BDNF activity and regulates genes linked to mood and emotion. In animal research, Semax reduced anxiety-like behavior and improved stress resistance. It may help promote a calmer, more focused state by supporting healthy brain function during mental or emotional strain. 

Does Semax Help With Brain Fog or Mental Fatigue? 

Semax may help reduce brain fog and mental fatigue by improving oxygen use and supporting neurotransmitter balance in the brain. Research shows it increases BDNF, which helps boost alertness and mental clarity. By protecting neurons from stress and improving communication between brain cells, Semax helps maintain focus, sharp thinking, and overall cognitive performance during periods of mental strain.

Is it Legal to buy in the U.S.? 

Semax is not approved by the U.S. Food and Drug Administration (FDA) for medical or supplement use. It is sold only for research purposes. Peptide regulations differ across states and regions, so local laws may affect where and how it can be purchased. Always check your local rules before ordering Semax.

Additional Reading
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This blog examines how peptides may help reduce brain fog during menopause, a common cognitive concern linked to hormonal fluctuations, stress, and aging. It discusses findings on peptides such as Semax, Selank, Epithalon and BPC-157, focusing on their potential to support memory, focus, mood and neural repair for better mental clarity.

Semax vs Selank

Semax vs Selank

This blog explores the comparison between Semax and Selank, two synthetic peptides studied for their distinct roles in neuroscience research. It discusses their influence on cognitive performance, stress response, and immune function, noting both their differences and complementary effects. Together, these compounds show promise in enhancing brain health and emotional balance through ongoing studies.

Best Nootropic Peptides For Boosting Brain Power

What Are The Best Nootropic Peptides For Boosting Brain Power?

This blog explores the intriguing field of nootropic peptides and their potential to improve memory, focus and overall cognitive performance. It highlights key compounds such as Selank, Semax and P-21, explaining their unique mechanisms from mood regulation to neuroprotection. These peptides show promise in supporting learning, brain health, and long-term mental resilience through ongoing research.

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