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AOD-9604 is a synthetic peptide made up of 15 amino acids. It comes from the C-terminal region of human growth hormone (hGH), specifically residues 176 to 191. Originally developed by Metabolic Pharmaceuticals in Australia, it was designed as a shorter, modified version of hGH to retain its fat-burning (lipolytic) properties.
Research on AOD-9604 has grown due to its key role in metabolism, especially in relation to obesity and fat regulation. Besides affecting lipid metabolism, the peptide is being studied for its potential use in tissue engineering, wound healing, and cartilage repair. Its targeted effects on fat tissue make it a promising tool for exploring metabolic disorders and fat-loss therapies, without disrupting other hormonal functions.
AOD-9604 works by targeting beta-3 adrenergic receptors, which are mostly found in fat tissue. When it binds to these receptors, it starts a chain reaction that raises the levels of cyclic adenosine monophosphate (cAMP). This activates protein kinase A (PKA), which then increases the activity of hormone-sensitive lipase (HSL). As a result, stored triglycerides break down into free fatty acids and glycerol (lipolysis).
At the same time, AOD-9604 reduces fat production (lipogenesis) by blocking acetyl-CoA carboxylase, an enzyme involved in fatty acid synthesis. Because it specifically targets beta-3 receptors, AOD-9604 focuses on fat cells and avoids the broader metabolic effects of full-length growth hormone, making it especially useful for studying fat metabolism independently.
Selective Fat Metabolism: Research has demonstrated that AOD focuses on fat tissue by activating beta-3 adrenergic receptors. It helps break down fat while maintaining lean muscle. Studies on obese mice showed that the peptide helps reduce fat. Interestingly, even in mice without beta-3 adrenergic receptors, fat reduction still occurred through increased energy use. This suggests AOD-9604 also works through other pathways beyond beta-3 receptors [1].
Enhanced Fat Breakdown Without Growth Side Effects: This peptide stimulates hormone-sensitive lipase (HSL), accelerating fatty acid breakdown while avoiding the growth-related effects typically associated with natural growth hormone. Isolating fat metabolism allows researchers to gain more precise insights into obesity, making it a valuable tool for focused metabolic studies. Studies in obese rats show reduced fat and smaller adipocytes, supporting its value as a safer, targeted candidate for obesity research [2].
Metabolic Research Applications: Scientific experiments have shown it is an essential research tool for diabetes, metabolic syndrome, and lipodystrophy, allowing precise study of beta-3 adrenergic pathways. Animal studies have demonstrated that it reduces weight gain and increases fat breakdown without affecting insulin sensitivity or causing genotoxicity, supporting its safety and value in long-term metabolic research [3].
Cartilage Regeneration Benefits: Studies show that this peptide boosts collagen synthesis in chondrocytes and helps reduce joint inflammation. In a recent study on rabbits with knee osteoarthritis, researchers found that combining AOD-9604 with hyaluronic acid was much more effective at repairing cartilage and reducing lameness than using either treatment alone. This dual action makes it valuable for studying tissue engineering applications and investigating cartilage repair mechanisms in degenerative joint conditions [4].
Improved Safety Profile: Studies have demonstrated that this peptide is able to help lower the occurrence of side effects related to the use of growth hormone, including insulin resistance, joint and muscle pain, and water retention. It has also been said not to raise IGF-1 levels, which helps reduce worries about cancer risks. This makes it a safer and more promising option for long-term studies [5].
Buy AOD-9604 Pre-Mixed Peptide from Peptide Works. The pre-mixed pen kit is available in 2mg cartridges, supplied with a cartridge pen, needle tips, and carry case.
[1] M Heffernan, R J Summers, A Thorburn, E Ogru, et al (2001). The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice – Endocrinology, 2001 Dec, Volume 142 (Issue 12), Pages 5182-9.
[2] F M Ng, W J Jiang, R Gianello, S Pitt, and P Roupas (2000). Molecular and cellular actions of a structural domain of human growth hormone (AOD9401) on lipid metabolism in Zucker fatty rats – Journal of Molecular Endocrinology, 2000 Dec, Volume 25 (Issue 3), Pages 287-98.
[3] F M Ng, J Sun, L Sharma, R Libinaka, et al (2000). Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone – Hormone Research, 2000, Volume 53 (Issue 6), Pages 274-8.
[4] D Rak Kwon and G Young Park (2015). Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model – Annals of Clinical and Laboratory Science, 2015 Summer, Volume 45 (Issue 4), Pages 426-32.
[5] M I. Mor̩ and D Kenley (2014). Safety and Metabolism of AOD9604, a Novel Nutraceutical Ingredient for Improved Metabolic Health РJournal of Endocrinology & Metabolism, Volume 4, Number 3, June 2014, Pages 64-77.
The answers to the most frequently asked questions about AOD-9604.
Buy AOD-9604 Peptide Nasal Spray from Peptide Works. The spray is available in 15ml and 30ml glass spray bottles.
Both peptides are derived from human growth hormone, focusing on fat metabolism without impacting IGF-1 levels. AOD-9604 is a modified version of HGH Fragment 176-191, with structural enhancements like a tyrosine modification to improve stability and receptor interaction. It also offers enhanced metabolic research capabilities and targeted effects.
Yes, it preserves muscle mass by specifically targeting fat metabolism. The peptide stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat formation) without directly affecting muscle proteins. This selective action ensures that during caloric deficits, the body prioritizes fat burning over muscle breakdown, helping maintain lean muscle tissue while reducing fat.
Yes, adverse effects may include pain, redness, or swelling at the injection site. Headaches, fatigue, and minor blood sugar changes may also occur. While it is generally safe for short-term use, the long-term effects are not well understood.
Yes, it is legal to buy AOD-9604 for research, however, it is not yet approved by the FDA (United States Food & Drug Administration) for human use.
AOD-9604 is primarily known for its fat-burning effects but may offer some potential joint health benefits, though research is limited. It might reduce inflammation, support collagen production for tissue repair, and improve recovery from physical stress. Additionally, its fat loss benefits could indirectly alleviate joint stress by reducing excess weight. However, more research is needed to fully establish its effects on joint health.
This blog looks at how effective AOD is as a weight loss peptide. It focuses on how it helps target fat metabolism, maintain muscle mass, and improve body composition. It discusses research findings, mechanisms of action, and its potential in obesity studies, emphasizing its selective fat-targeting properties and metabolic health benefits.
This blog looks at how the AOD-9604 peptide can help repair cartilage by boosting collagen production and reducing joint inflammation.It delves into research findings, mechanisms of action, and comparisons with other peptides like TB500 and BPC-157, highlighting their roles in tissue repair, extracellular matrix restoration, and blood vessel growth.
This blog examines whether IGF-1 LR3 peptide is effective for fat loss, focusing on its ability to enhance lipolysis, preserve muscle mass, and activate fat metabolism pathways. It explores the peptide's mechanisms, including IGF-1 receptor activation, and its role in brown fat activation, offering insights into its potential for targeted fat reduction research.
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Peptide Works website: https://peptide-works.com/ is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
