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Selank is a synthetic peptide, created based on tuftsin, a natural peptide important for immune system regulation. It’s primarily known for its nootropic (cognitive-enhancing) and anxiolytic (anxiety-reducing) effects. This makes Selank a popular subject in research focused on mental health and cognitive improvement.
Scientists are exploring its ability to reduce anxiety, improve memory, and enhance focus, without the sedation often seen with traditional anxiety medications. Selank also shows potential in boosting the immune system, making it useful for researching both mental and physical health.
Peptide Sequence (IUPAC Condensed): H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH
Molecular Formula: C33H57N11O9
Molecular Weight: 751.9 g/mol
Synonyms: Selanc, TP-7
View the Selank COA
View the Selank HPLC
Research shows Selank interacts with neurotransmitters to affect the central nervous system. It alters serotonin, dopamine, and norepinephrine levels, which are important for focus, mood regulation, and stress response. Brain-derived neurotrophic factor (BDNF), which promotes memory and cognitive function, is also expressed more when selanka is taken.
It is a distinctive substitute for conventional anti-anxiety drugs because it produces its anxiolytic effects without sedating users. Additionally, selanka aids in controlling cytokine levels, which maintains immunological balance. Because of these effects, it is a promising field for research on immune system support, mental health, and cognitive enhancement.
Buy Selank Peptide 5mg Vial from Peptide Works. This lyophilized powder is over 99% pure and is supplied in sterile glass vials for optimal stability and performance.
Anxiolytic (anti-anxiety) and stress-relieving effects: Studies indicate that Selank offers potent anxiolytic and stress-relieving effects, rivaling benzodiazepines such as Medazepam. However, it stands out by also providing psychostimulant and energy-boosting benefits, making it a uniquely versatile option.
In a clinical study of patients with generalized anxiety disorder (GAD) and neurasthenia, Selank reduced anxiety while improving energy and reducing fatigue. Mechanistically, it modulates the GABAergic system, enhancing GABA activity, and influences serotonin and dopamine pathways, providing a calming effect without sedation [1].
In animal studies, Selank enhanced the anxiolytic effects of Diazepam under chronic mild stress and protected against stress-induced anxiety indicators, highlighting its potential as a versatile and non-sedative treatment for anxiety and stress-related conditions [2].
Cognitive enhancement (memory, learning, attention): Selank has been shown to have cognitively enhancing properties that improve learning, memory, and attention. Underperforming rats’ learning abilities were improved by selank (300 µg/kg). In an active avoidance task, it considerably decreased errors and increased correct responses. With repeated doses, the effect became more pronounced. Selank was more effective than piracetam at maximizing learning, particularly in rats experiencing emotional stress [3].
Additionally, Selank controlled the expression of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex and hippocampus, preventing memory and attention deficits in a study of chronic ethanol-induced cognitive impairment. Selank promotes neuroplasticity and neuronal health by upregulating BDNF, which makes it a viable option for both neuroprotection and cognitive enhancement [4].
Neuroprotective and Immune-Modulating Effects: Research shows that Selank exhibits neuroprotective and immunomodulatory effects, likely due to its derivation from tuftsin, an immunomodulatory peptide. It influences cytokine levels, regulates inflammatory gene expression, and stabilizes enkephalins, enhancing resilience under stress.
In studies, Selank altered the expression of 34 inflammation-related genes, including Bcl6, which is critical for immune system development [5]. It also restored immune balance in stress models, improving phagocytic activity and cellular immunity.
In patients with generalized anxiety disorder, Selank increased enkephalin levels, correlating with reduced anxiety and fatigue [6]. Additionally, its ability to upregulate BDNF in the hippocampus and prefrontal cortex suggests neuroprotective effects, particularly under stress or alcohol-induced damage [7].
Buy Selank Pre-Mixed Peptide from Peptide Works. The pre-mixed pen kit comes in 5mg cartridges, complete with a cartridge pen, needle tips, and carry case for ease and precision.
[1] A A Zozulia, G G Neznamov, T S Siuniakov, et al (2008) [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia] – Zh Nevrol Psikhiatr Im S S Korsakova, 2008, Volume 108 (Issue 4), Pages 38-48.
[2] A Kasian, T Kolomin, L Andreeva, et al (2017) Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats – Behavioral Neurology, 2017, Volume 2017, Page 5091027.
[3] I I Kozlovskii and N D Danchev (2003) The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats – Neuroscience & Behavioral Physiology, 2003 Sep, Volume 33 (Issue 7), Pages 639-43.
[4] L G Kolik, A V Nadorova, T A Antipova, et al (2019) Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats – Bulletin of Experimental Biology and Medicine, 2019 Sep, Volume 167 (Issue 5), Pages 641-644.
[5] T Kolomin, M Shadrina, L Andreeva, et al (2011) Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank – Regulatory Peptides, Volume 170, Issues 1–3, 10 October 2011, Pages 18-23.
[6] O N Uchakina, P N Uchakin, N F Miasoedov, et al (2008) [Immunomodulatory effects of selank in patients with anxiety-asthenic disorders] – Zh Nevrol Psikhiatr Im S S Korsakova, 2008, Volume 108 (Issue 5), Pages 71-5.
[7] Y A Leonidovna, S M Aleksandrovna, T A Aleksandrovna, et al (2021) The Influence of Selank on the Level of Cytokines Under the Conditions of “Social” Stress – Current Reviews of Clinical Experimental Pharmacology, 2021, Volume 16 (Issue 2), Pages 162-167.
The answers to the most frequently asked questions about Selank.
Buy Selank Peptide Nasal Spray from Peptide Works. The spray is available in 15ml and 30ml glass bottles, offering a needle-free and convenient administration method.
Selank promotes calm focus and supports a healthy stress response through its action on GABA and serotonin pathways. Research shows it may reduce anxiety, enhance memory, and improve learning ability. Studies also note immune-modulating effects, lowering inflammatory cytokines while supporting balance in brain signaling. Selank’s neuroprotective properties suggest potential benefits for mood stability, cognitive clarity, and overall mental resilience.
Selank works by helping brain chemicals stay in balance. It supports the activity of GABA and serotonin, which calm the nervous system and improve focus. This action can reduce feelings of stress and anxiety while promoting clear thinking. Studies also show Selank may influence genes that protect brain cells, helping the mind stay stable, focused, and better able to handle daily pressure.
Selank is generally well tolerated in studies, with few adverse effects reported. When observed, reactions are mild and temporary. Because responses can differ, researchers typically begin with the lowest effective experimental dose and monitor outcomes carefully. Use high-quality Selank peptide in research and follow proper handling and dosing guidelines to ensure safety and consistency in results.
Selank is not approved by the U.S. Food and Drug Administration (FDA) for human use. In the United States, it can be purchased legally for laboratory and research purposes only. Selank is classified as a research-use-only peptide and is not intended for medical or dietary applications. Laws and regulations may vary by region, so it is important to review local requirements before purchasing.
This blog explores the intriguing field of nootropic peptides and their potential to improve memory, focus and overall cognitive performance. It highlights key compounds such as Selank, Semax and P-21, explaining their unique mechanisms from mood regulation to neuroprotection. These peptides show promise in supporting learning, brain health, and long-term mental resilience through ongoing research.
This blog explores the potential of Selank peptide in treating autoimmune disorders. It delves into how Selank may modulate cytokine activity, reduce inflammation and support immune balance. The blog also compares Selank with other peptides like Humanin and Epithalon, highlighting their roles in oxidative stress, mitochondrial health and immune stability in autoimmune research.
This blog explores the comparison between Semax and Selank, two synthetic peptides studied for their distinct roles in neuroscience research. It discusses their influence on cognitive performance, stress response, and immune function, noting both their differences and complementary effects. Together, these compounds show promise in enhancing brain health and emotional balance through ongoing studies.
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Peptide Works website: https://peptide-works.com/ is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
