Buy ARA-290 Peptide

Reduces Inflammation: Research has shown the peptide to offer anti-inflammatory and neuroprotective effects without stimulating hematopoiesis. A study on rats with experimental autoimmune encephalomyelitis (EAE) showed that ARA significantly reduced disease severity and inflammation. It worked by suppressing pro-inflammatory cytokines, reducing T-cell activity, and encouraging Th2 and Treg cells while blocking Th1 and Th17 cells [1].

Additionally, studies on colitis demonstrated that activation of the innate repair receptor (IRR), a heteromer of the EPO receptor (EPOR) and CD131, reduced inflammatory pathways and improved immune response. Treatment preserved tissue integrity, reduced myeloid cell infiltration, and diminished pro-inflammatory mediators [2]. These studies highlight ARA290’s potential for autoimmune disorders like multiple sclerosis and inflammatory bowel disease.

Relief for Neuropathic Pain: Scientific research indicates that this peptide could be a painkiller or a tissue-protective agent for such diseases as diabetes and cancer. Its analgesia is largely attributed to its anti-inflammatory and immune-modulating effects through the innate repair receptor (IRR).

A 2016 study suggested that it might also act directly on peripheral nociceptors by inhibiting TRPV1 channel activity, alleviating capsaicin-triggered pain. In live mice, ARA290 reduced paw withdrawal responses, demonstrating its potential for treating small nerve fiber loss and neuropathic pain [3].

Additionally, its anti-inflammatory effects have shown promise in systemic lupus erythematosus (SLE), reducing inflammatory cytokines and improving tissue protection [4]. By targeting dorsal root ganglion neurons, ARA290 may also address pain linked to thyroid dysfunction, offering new therapeutic opportunities for immune and nervous system disorders.

Tissue Repair & Healing: This peptide helps protect and heal tissue by activating the innate repair receptor (IRR), reducing inflammation, and speeding up wound healing in chronic diabetes.

In studies on diabetic wound models, ARA-290 was shown to improve collagen production, increase protein content and antioxidant levels, and lower inflammatory cytokines. This highlights its potential as a therapeutic option for diabetes-related wound healing [5].

Improves Metabolic Control: ARA-290 enhances metabolic control in type 2 diabetes by improving HbA1c levels, lipid profiles, and cardiovascular risk factors. It helps improve pancreatic islet cell function, boosting glucose oxidation, ATP production, and insulin secretion to support better glucose regulation. Additionally, it eases neuropathic symptoms and helps protect against complications like diabetic retinopathy and nephropathy [6].

Cardiovascular Health: Aging is associated with higher levels of inflammation, oxidative stress, and mitochondrial problems, which can lead to frailty and heart issues. Researchers tested ARA290 on aged rats over 15 months and found it reduced heart inflammation, fibrosis, and pro-inflammatory markers.

It also improved mitochondrial function, autophagy, and overall heart structure. It preserved heart function, lowered blood pressure, reduced frailty, and ultimately extended healthspan while slowing age-related decline [7].

Regenerates Corneal Nerves: Research has shown that the selective IRR agonist enhances corneal nerve regeneration, relieves neuropathic pain and enhances the quality of life for patients with sarcoidosis and type 2 diabetes. By activating anti-inflammatory and tissue repair pathways, it facilitates recovery from nerve damage with minimal side effects. More research is needed to confirm its long-term benefits [8].

Buy ARA-290 Pre-Mixed Peptide from Peptide Works for research purposes. The pre-mixed pen kit is available in 2mg cartridges, supplied with a cartridge pen, needle tips, and a carry case.