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Buy CJC-1295 no DAC Peptide

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What Is CJC-1295 no DAC Peptide?

CJC-1295 no DAC is a synthetic peptide analog of growth hormone-releasing hormone (GHRH), designed for research purposes to study its effects on growth hormone secretion. Unlike its counterpart with DAC (Drug Affinity Complex), this version lacks the DAC component, resulting in a shorter half-life and reduced duration of action.

It is made up of 29 amino acids and is designed to mimic natural GHRH, making it a useful tool for studying growth hormone pathways. Researchers use it to look into how it works in the body, its potential benefits, and how it might help with muscle growth, recovery, and hormonal changes as we age.

Peptide Sequence (IUPAC Condensed): H-DL-Tyr-DL-Ala-DL-Asp-DL-Ala-DL-xiIle-DL-Phe-DL-xiThr-DL-Gln-DL-Ser-DL-Tyr-DL-Arg-DL-Lys-DL-Val-DL-Leu-DL-Ala-DL-Gln-DL-Leu-DL-Ser-DL-Ala-DL-Arg-DL-Lys-DL-Leu-DL-Leu-DL-Gln-DL-Asp-DL-xiIle-DL-Leu-DL-Ser-DL-Arg-NH2

Molecular Formula: C152H252N44O42

Molecular Weight: 3367.9 g/mol

Synonyms: Modified GRF 1-29, Mod GRF 1-29, CJC-1295 without DAC

View the CJC-1295 no DAC Certificate Of Analysis (COA)

View the CJC-1295 no DAC High Performance Liquid Chromatography (HPLC)

All our peptides are guaranteed a purity of +99%. Third party lab testing is available upon request.

CJC-1295 No DAC Structure
Source: PubChem
Buy CJC-1295 no DAC

How Does CJC-1295 no DAC Peptide Work?

CJC-1295 no DAC functions by mimicking the body’s own growth hormone-releasing hormone, or GHRH. It works by attaching itself to GHRH receptors in the anterior pituitary gland, which leads to the activation of a signaling pathway known as cAMP, or cyclic adenosine monophosphate. As a result, it stimulates the pituitary gland to secrete growth hormone (GH) into the bloodstream in a way that aligns with the body’s natural rhythms of hormone secretion.

Unlike CJC-1295 with DAC, the no-DAC version has a shorter half-life, remaining active for a limited time and offering only temporary stimulation of growth hormone (GH) release. Researchers are examining its impact on the somatotropic axis to better understand its effects on growth, recovery, and metabolism.

Buy CJC-1295 No DAC Peptide Vial from Peptide Works for laboratory research use. This high-purity lyophilized peptide (over 99%) is available in 2mg, 5mg, and 10mg vials or as complete kits supplied with bacteriostatic water and syringes for easy reconstitution.

Research on CJC-1295 no DAC Peptide?

Increased GH and IGF-1 Levels: Mod GRF 1-29 transiently stimulates growth hormone production by targeting the pituitary gland, leading to pulsatile increases in GH levels and secondary rises in IGF-1 [1]. Clinical trials, including studies on GHRH gene ablation and human consumption, demonstrated dose-dependent, sustained IGF-1 elevation with preserved growth hormone synthesis. These findings highlight its potential for supporting muscle strength, maintaining normal body weight, and optimizing peptide hormone function [2].

Improved Body Composition and Weight Loss: This peptide boosts natural growth hormone and increases IGF-1 levels. This pulsatile release helps build muscle, maintain lean body mass, and reduce fat [3].

Studies on animals, specifically GHRH-knockout mice, showed better body composition, including more lean tissue and less fat, after treatment [4]. More frequent dosing can even enhance these results. While human data is still limited, evidence suggests that increasing GH-IGF-1 activity can improve muscle mass and decrease both visceral and subcutaneous fat.

Better Sleep: Research suggests that modified GRF enhances GH and IGF-1 levels, which are linked to sleep regulation. Studies show that GH deficiency is associated with increased slow-wave sleep (SWS) intensity, likely due to overactive hypothalamic GHRH.

GH replacement therapy, including agents like CJC-1295, can normalize this by reducing excessive SWS intensity and improving sleep patterns. CJC-1295’s sustained GH release may support better sleep regulation, though its direct effects on sleep require further study [5].

Enhanced Cognitive Function: Research has shown that CJC-1295 without DAC may support cognitive function by enhancing growth hormone (GH) and IGF-1 levels, which are critical for brain health. Studies show that GHRH administration improves executive function and verbal memory in both healthy older adults and those with mild cognitive impairment (MCI) [6].

Additionally, GH has neuroprotective effects, promoting recovery in stroke models by aiding spatial memory and neuronal repair. These findings suggest CJC-1295’s potential to enhance cognitive performance and support brain health during aging and neurodegenerative conditions [7].

Cardioprotective: Research has shown that GRF 1-29 exhibits cardioprotective properties by activating cardiac repair mechanisms independent of the GH/IGF-1 axis. Studies show GHRH agonists like JI-38 improve cardiac function, reduce remodelling, and enhance anti-apoptotic gene expression after myocardial infarction (MI) [8].

Unlike IGF-1, which modulates inflammation and promotes anti-inflammatory macrophages, GHRH agonists directly stimulate cardiac precursor cell proliferation and repair, offering a promising therapeutic pathway for heart injury recovery [9].

Wound Healing and Tissue Repair: Research indicates that CJC-1295 no DAC supports wound healing and tissue repair by stimulating growth hormone (GH) release, which enhances IGF-1 production. IGF-1 promotes keratinocyte migration, wound epithelialization, and hyaluronan synthesis, aiding in challenging wound recovery, such as burns and diabetic ulcers [10].

Additionally, GH improves collagen deposition, angiogenesis, and granulation tissue formation while reducing inflammation, as seen in intestinal healing models. These combined effects highlight its potential in accelerating tissue repair [11].

Buy CJC-1295 no DAC Pre-Mixed Pen for in vitro testing and laboratory experimentation. There is the option to buy individual cartridges or a pen kit, which includes an injection pen, single use pen needle tips, and a single cartridge containing CJC-1295 no DAC pre-mixed with bacteriostatic water.

References

[1] Ionescu M, Frohman LA (2006) Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog – J Clin Endocrinol Metab. 2006 Dec, Volume 91 (Issue 12), Pages 4792-7.

[2] S L Teichman, A Neale, B Lawrence, C Gagnon, et al (2006) Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults – The Journal of Clinical Endocrinology & Metabolism, Volume 91, Issue 3, 1 March 2006, Pages 799–805.

[3] L Sackmann-Sala, J Ding, L A Frohman, and J J Kopchick (2009) Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects – Growth Hormone & IGF Research, 2009 Dec, Volume 19 (Issue 6), Pages 471-7.

[4] M Alba, D Fintini, A Sagazio, B Lawrence, et al (2006) Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse – American Journal of Physiology, Endocrinology & Metabolism, 2006 Dec, Volume 291 (Issue 6), Pages E1290-4.

[5] L L Morselli, A Nedeltcheva, R Leproult, et al (2013) Impact of growth hormone replacement therapy on sleep in adult patients with growth hormone deficiency of pituitary origin – European Journal of Endocrinology, 2013 Apr 15, Volume 168 (Issue 5), Pages 10.1530/EJE-12-1037.

[6] L D Baker, S M Barsness, S Borson, et al (2012) Effects of Growth Hormone–Releasing Hormone on Cognitive Function in Adults With Mild Cognitive Impairment and Healthy Older Adults – Arch Neurol, 2012 Nov, Volume 69 (Issue 11), Pages 1420–1429.

[7] P Pathipati, A Surus, C E Williams, et al (2009) Delayed and chronic treatment with growth hormone after endothelin-induced stroke in the adult rat – Behavioural Brain Research, Volume 204, Issue 1, 1 December 2009, Pages 93-101.

[8] R M Kanashiro-Takeuchi, K Tziomalos, L M Takeuchi, et al (2010) Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction – Proc Natl Acad Sci U S A, 2010 Jan 21, Volume 107 (Issue 6), Pages 2604–2609. 

[9] A Heinen, R Nederlof, P Panjwani, et al (2018) IGF1 Treatment Improves Cardiac Remodeling after Infarction by Targeting Myeloid Cells – Molecular Therapy, 2018 Nov 1, Volume 27 (Issue 1), Pages 46–58. 

[10] Z Garoufalia, A Papadopetraki, E Karatza, et al (2021) Insulin-like growth factor-I and wound healing, a potential answer to non-healing wounds: A systematic review of the literature and future perspectives – Biomedical Reports, 2021 Jun 8, Volume 15 (Issue 2), Page 66.

[11] M A Küper, S Trütschel, J Weinreich, et al (2016) Growth hormone abolishes the negative effects of everolimus on intestinal wound healing – World Journal Gastroenterology, 2016 May 7, Volume 22 (Issue 17), Pages 4321–4329.

CJC-1295 no DAC Peptide FAQ's

The answers to the most frequently asked questions about CJC-1295 no DAC.
CJC-1295 No DAC FAQs

Buy CJC-1295 No DAC Peptide Nasal Spray from Peptide Works for scientific research. Offered in 15 ml and 30 ml glass spray bottles, this non-invasive option provides a simple and effective administration route for research applications.

 
What is the Recommended Dosing Frequency and Cycle for CJC-1295 no DAC?

CJC-1295 no DAC has a short half-life, so it is typically prepared for multiple daily administrations to maintain consistent release patterns. Dosing intervals are often spaced several hours apart. Cycles usually last a few weeks, followed by a break period before repeating to support controlled and measurable results.

What are the Side Effects of CJC-1295 no DAC?

Possible side effects may include mild redness at the injection site, temporary water retention, or slight changes in energy and appetite levels. These reactions can depend on factors such as peptide purity, concentration, and handling conditions. Proper preparation and storage help minimize unwanted variations in response.

Can CJC-1295 no DAC Be Stacked with Other Peptides?

The CJC-1295 no DAC and Ipamorelin blend is a popular combination among researchers for its ability to optimize growth hormone levels. This ipamorelin peptide stack enhances growth hormone secretagogue effects by targeting the growth hormone secretagogue receptor, promoting a smoother, pulse-like release of GH. Clinical studies and research from organizations like the International IGF Research Society highlight its role in maintaining positive nitrogen balance, supporting urea cycle enzymes, and inducing conformational changes in pituitary RNA. Accurate preparation and timing are crucial for reliable outcomes in controlled studies, particularly for animal consumption and advanced growth hormone research.

Is it safe and legal to buy CJC-1295 no DAC in the USA?

It is legal to buy cjc-1295 no dac for research only. The United States Food and Drug Administration, often referred to as FDA, has not approved the peptide for animal or human consumption.

Can I buy CJC-1295 no DAC in bulk or larger quantities?

Yes you can buy cjc-1295 no dac in bulk. Contact our customer service team to discuss the possibility of a discount on bulk orders.

Additional Reading
Is CJC Safer than HGH peptides

Is CJC Safer than HGH Peptides?

This blog examines the safety differences between CJC-1295 and HGH peptides in research settings. It highlights CJC-1295’s ability to support natural growth hormone rhythms, reduce receptor desensitization, and minimize blood sugar impacts. The blog also explores injection site reactions, cardiovascular considerations, and dosing protocols, emphasizing the importance of quality standards in peptide research.

CJC-1295 Without DAC

Is CJC-1295 Without DAC Safer?

This blog explores the benefits and safety profile of CJC-1295 no DAC, a short-acting growth hormone secretagogue. Unlike the DAC version, it mimics the body's natural hormone cycles, which helps reduce the risk of receptor fatigue and long-term complications. The blog highlights its potential to support fat loss, enhance metabolism, and enable safer research applications, all while working in harmony with the body’s biological rhythms.

Benefits of Combining Ipamorelin and CJC-1295

The Benefits of Combining Ipamorelin and CJC-1295

This blog takes a closer look at the synergistic benefits of combining Ipamorelin and CJC-1295 in peptide research. It explains how these two compounds work together to support the release of growth hormone, with potential links to muscle recovery, fat metabolism, sleep quality, and visible signs of aging. The comparison of DAC and No-DAC forms offers researchers a clearer view of their distinct applications.

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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Peptide Works website: https://peptide-works.com/ is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.