Tesofensine vs Tesamorelin : Which Is Best For Weight Loss?
With obesity on the rise and the associated health risks involved, researchers are constantly working to find cost effective and safe treatments to combat this global issue. Two compounds that are popular with researchers are Tesofensine and Tesamorelin.
But which one is more cost effective and better suited for safe weight loss? In this article, Peptide Works looks at their differences, examining how they work, their safety features, and potential applications to help researchers choose the best peptide for their specific study.
What Are Weight Loss Peptides?
Weight loss peptides, like Tesofensine, and Tesamorelin, are short amino acid chains that help with fat reduction and weight management. They work by targeting key areas like appetite control, metabolism, and fat breakdown.
Unlike traditional methods of weight loss, these peptides address deeper issues like hormonal imbalances or slow metabolism. While these peptides are effective, it’s very important to know about any potential side effects. It is also crucial to consult with a healthcare professional before starting any new clinical study.
Tesofensine vs Tesamorelin: What makes these peptides unique?
Before starting any study, it’s important to understand how each peptide actually works:
Tesofensine: This peptide acts as a serotonin noradrenaline dopamine reuptake inhibitor (SNDRI). Simply put, it works by blocking the reabsorption of three key brain chemicals: serotonin, noradrenaline, and dopamine, after they’ve sent signals between brain cells.
This keeps these chemicals active in the brain for longer, helping to regulate mood, appetite, and energy levels. By doing so, Tesofensine can help reduce hunger, improve mood, and boost motivation. This makes it an effective option for tackling issues like obesity and certain mood disorders, as it helps control food intake and enhances metabolism to support weight loss.
Tesamorelin: This is a growth hormone-releasing peptide that reduces abdominal fat by increasing human growth hormone (HGH) levels. It works by stimulating the release of growth hormone-releasing hormone (GHRH), prompting the pituitary gland to produce more HGH. This helps improve metabolism, reduce visceral fat, and support muscle development.
HGH reduces fat by breaking down stored fats into energy while preventing the formation of new fat cells. It also promotes a healthier fat distribution, particularly reducing harmful visceral fat. By mimicking natural GHRH, Tesamorelin provides a controlled and effective option for improving body composition and supporting overall metabolic health.
What Are the Different Types of Fat?
The human body stores several different types of fat, each with unique functions and health impacts. The main types of fat include:
Subcutaneous Fat: This is the fat stored directly under the skin and is the most visible type of fat. While it serves as an energy reserve and helps with insulation and cushioning, excessive subcutaneous fat may contribute to health issues such as obesity.
Visceral Fat: Found around internal organs like the liver, pancreas, and intestines, visceral fat is less visible but more harmful. High levels of visceral fat are linked to increased risks of heart disease, type 2 diabetes, and metabolic syndrome.
Essential Fat: Essential fat is required for the normal functioning of the body. It is found in organs, bones, and tissues and plays a critical role in hormone regulation, temperature control, and overall body health.
Brown Fat: Brown fat, or brown adipose tissue, is a specialised type of fat that generates heat by burning calories. It is more prevalent in infants and diminishes with age, but its activation is associated with improved metabolic health.
White Fat: This is the most abundant fat in the body, storing energy for long-term use and providing cushioning and insulation. However, an excess of white fat can lead to obesity and associated health conditions.
Each type of fat has unique roles, and maintaining a healthy balance is crucial for overall well-being. While some fat, such as essential and brown fat, supports health, managing excess visceral and white fat is key to minimising health risks.
How Can These Compounds Benefit Your Research?
Key Benefits of Tesofensine:
- Clinical studies have shown Tesofensine to reduce body weight by 10–14% within a three month period.
- Research shows that it helps boost dopamine levels. This helps to improve mood and motivation and could potentially be beneficial for people who “emotionally eat”.
- It helps reduce appetite in a way that doesn’t lead to overeating later to compensate.
- It promotes thermogenesis, which helps the body burn stored fat as energy while also serving as insulation to regulate body temperature.
Key Benefits of Tesamorelin:
- Clinical studies have shown an 18% reduction in abdominal fat after six months.
- It is suggested to be more effective for visceral fat reduction, especially in cases such as HIV-related lipodystrophy
- Results from research have shown improvements in both lean body mass and glucose metabolism.
How Safe Are Tesofensine and Tesamorelin?
Peptide Works advises understanding the peptide’s safety profile, before commencing any clinical studies. Both Tesofensine and Tesamorelin have been studied extensively, with studies providing valuable insights into their potential risks and benefits. This section will explore their safety, helping you make informed decisions about their use.
Safety Profile of Tesofensine:
Initial trials for Tesofensine look promising, but it’s important to keep an eye on potential side effects like dry mouth, insomnia, and a faster heart rate. If any of your patients have a heart condition, it’s best to approach with caution.
Safety Profile of Tesamorelin:
Tesamorelin is FDA approved for treating HIV associated lipodystrophy, but it can cause side effects like joint pain, swelling, or allergic reactions. It’s important to monitor regularly, especially blood sugar levels, to stay on top of any potential issues.
Which Is More Convenient to Use?
Here’s a quick comparison on adminitering the peptides:
- Tesofensine: Oral capsules offer a convenient and practical option for researchers exploring Tesofensine. They’re easy to incorporate into daily study protocols, ensuring a seamless fit into ongoing research routines.
- Tesamorelin: Most commonly administered via injections, Tesamorelin requires effort and regular monitoring. While pre-mixed pens simplify the process by eliminating the need for reconstitution, they are still an injection and remain more invasive compared to Tesofensine. However, Peptide Works also offers Tesamorelin in a nasal spray format, providing researchers with a lot more flexibility.
Cost Considerations
Peptide Works understands that research budgets can sometimes be tight, so we have given you cost information to consider:
Tesofensine is often seen as a more affordable option, making it attractive for general weight management. Its lower cost and wider range of applications have sparked interest among researchers looking for large-scale solutions to combat obesity.
On the other hand, Tesamorelin is much more expensive due to its specific focus on reducing visceral fat. Its targeted action, combined with the complexity and cost of production and administration, drives its higher price.
This creates an interesting comparison for researchers. Tesofensine offers a more accessible option for general weight management, while Tesamorelin’s specialized use could be crucial for conditions where visceral fat plays a key role, such as metabolic disorders.
Exploring the cost-benefit balance of these two compounds could lead to new, more tailored treatment options and advancements in weight-related health research.
Tesofensine vs Tesamorelin Summary
| Feature | Tesofensine | Tesamorelin |
|---|---|---|
| How it works | Appetite suppression via SNDRI | Growth hormone stimulation |
| Main benefit | General weight loss | Reduces visceral fat |
| Convenience | Oral capsules (high convenience) | Injectable or nasal spray (lower convenience) |
| Studies on weight loss | Results = 10–14% reduction in 3 months | Results = 18% reduction in abdominal fat in 6 months |
| Price | Cost effective for general use | More expensive, specific applications |
| FDA approval | No | Yes (HIV-related lipodystrophy only) |
| Side effects | Dry mouth, insomnia, mild cardiovascular issues | Joint pain, swelling, glucose intolerance risk |
So Which One Should You Choose?
- Tesofensine: This is ideal for researchers with broader weight loss objectives and for those needing an easy to use, non-invasive treatment method.
- Tesamorelin: This is more suitable for targeted fat reduction, particularly visceral fat. It’s a strong candidate for clinical applications in specific populations, such as those with lipodystrophy.
Final Verdict
Both Tesofensine and Tesamorelin offer unique pathways to achieving weight loss goals. Your choice between the two should depend on your individual research requirements, preferences, and medical considerations.
If you’re interested in further exploring these compounds, Peptide Works provides a range of research-focused Tesofensine capsules and Tesamorelin peptides for study purposes. Always ensure compliance with local regulations when using these compounds for research or medical studies.
References
[1] Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159.
[2] Russo SC, Ockene MW, Arpante AK, Johnson JE, Lee H, Toribio M, Stanley TL, Hadigan CM, Grinspoon SK, Erlandson KM, Fourman LT. Efficacy and safety of tesamorelin in people with HIV on integrase inhibitors. AIDS. 2024 Oct 1;38(12):1758-1764.
[3] Perez CI, Luis-Islas J, Lopez A, Diaz X, Molina O, Arroyo B, Moreno MG, Lievana EG, Fonseca E, Castañeda-Hernández G, Gutierrez R. Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons. PLoS One. 2024 Apr 24;19(4):e0300544. doi: 10.1371/journal.pone.0300544.
[4] Lake JE, La K, Erlandson KM, Adrian S, Yenokyan G, Scherzinger A, Dubé MP, Stanley T, Grinspoon S, Falutz J, Mamputu JC, Marsolais C, McComsey GA, Brown TT. Tesamorelin improves fat quality independent of changes in fat quantity. AIDS. 2021 Jul 15;35(9):1395-1402.
[5] Adrian S, Scherzinger A, Sanyal A, Lake JE, Falutz J, Dubé MP, Stanley T, Grinspoon S, Mamputu JC, Marsolais C, Brown TT, Erlandson KM. The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV. J Frailty Aging. 2019;8(3):154-159.
[6] Nathan PJ, O’Neill BV, Napolitano A, Bullmore ET. Neuropsychiatric adverse effects of centrally acting antiobesity drugs. CNS Neurosci Ther. 2011 Oct;17(5):490-505.
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